Why IBS-C Treatments Work Differently for Everyone: What Patients Should Know

Why does one IBS-C treatment work for someone else—but not for you?

In this episode of the Gastro Girl podcast, leading gastroenterologist Darren M. Brenner. MD, FACG, of Northwestern Medicine, explains why treating IBS-C (irritable bowel syndrome with constipation) is not one-size-fits-all.

Using a real-world patient scenario, Dr. Brenner breaks down what may actually be happening inside the body—from gut motility and visceral sensitivity to the brain-gut connection—and why different therapies target different symptoms and pathways.

In this episode, you’ll learn:

– Why some IBS-C treatments don’t work—or stop working over time
– How over-the-counter and prescription therapies differ
– What newer treatment approaches are designed to do
– Why bloating, pain, and constipation may require different strategies
– The role of diet, pelvic floor therapy, and gut-brain interventions
– How patients can work with their healthcare team to find the right treatment plan

If you’ve ever felt frustrated, stuck, or unsure about your IBS-C treatment journey, this episode offers practical insights to help you better understand your options and feel more empowered in your care.

This episode is part of an educational program made possible by support from Ardelyx.