Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort — Results of an International Multicenter Randomized Controlled Trial

INTRODUCTION:

Consumption of green kiwifruit is known to relieve constipation. Previous studies have also reported improvements in gastrointestinal (GI) comfort. We investigated the effect of consuming green kiwifruit on GI function and comfort.

METHODS:

Participants included healthy controls (n = 63), patients with functional constipation (FC, n = 60), and patients with constipation-predominant irritable bowel syndrome (IBS-C, n = 61) randomly assigned to consume 2 green kiwifruits or psyllium (7.5 g) per day for 4 weeks, followed by a 4-week washout, and then the other treatment for 4 weeks. The primary outcome was the number of complete spontaneous bowel movements (CSBM) per week. Secondary outcomes included GI comfort which was measured using the GI symptom rating scale, a validated instrument. Data (intent-to-treat) were analyzed as difference from baseline using repeated measures analysis of variance suitable for AB/BA crossover design.

RESULTS:

Consumption of green kiwifruit was associated with a clinically relevant increase of ≥ 1.5 CSBM per week (FC; 1.53, P < 0.0001, IBS-C; 1.73, P = 0.0003) and significantly improved measures of GI comfort (GI symptom rating scale total score) in constipated participants (FC, P < 0.0001; IBS-C, P < 0.0001). No significant adverse events were observed.

DISCUSSION:

This study provides original evidence that the consumption of a fresh whole fruit has demonstrated clinically relevant increases in CSBM and improved measures of GI comfort in constipated populations. Green kiwifruits are a suitable dietary treatment for relief of constipation and associated GI comfort.

Gearry, Richard MD, PhD*,1; Fukudo, Shin MD, PhD*,2,3; Barbara, Giovanni MD*,4; Kuhn-Sherlock, Barbara PhD5; Ansell, Juliet PhD6; Blatchford, Paul PhD6; Eady, Sarah MSc7; Wallace, Alison PhD7; Butts, Christine PhD7; Cremon, Cesare MD4; Barbaro, Maria Raffaella PhD4; Pagano, Isabella MD4; Okawa, Yohei PhD2; Muratubaki, Tomohiko PhD2; Okamoto, Tomoko PhD8; Fuda, Mikiko MS9; Endo, Yuka MD3; Kano, Michiko MD, PhD2; Kanazawa, Motoyori MD, PhD2,3; Nakaya, Naoki PhD10; Nakaya, Kumi PhD10; Drummond, Lynley BTech (Hons)11