Oh My ‘Gogues! IBS-C Treatments Explained: Secretagogues & Retainagogues

Finding the right treatment for Irritable Bowel Syndrome with Constipation (IBS-C) can feel overwhelming, but understanding how different therapies work can make all the difference. In this episode, we dive deep into two key treatment categories: secretagogues and retainagogues—what they are, how they work, and why they matter for IBS-C patients.

Joining us is Dr. Darren Brenner, a leading expert in neurogastroenterology and motility disorders from Northwestern University. He breaks down the science behind these treatments, shares expert insights, and helps us understand when and why providers may recommend them.

Don’t miss this expert-led conversation that makes IBS-C treatments clearer than ever!

This episode is made possible with support from Ardelyx.

This episode is made possible with support from:

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Featured Guests in this Episode

Darren M. Brenner, MD

Associate Professor of Medicine and Surgery in the Division of Gastroenterology at Northwestern University

Dr. Brenner is an Associate Professor of Medicine and Surgery in the Division of Gastroenterology at Northwestern University and serves as Director of the Neurogastromotility and Functional Bowel Programs, Co-Director of the Integrated Bowel Dysfunction program, and Director of the Motts Tonelli GI Physiology Laboratory. He is also an active Irene D. Pritzker Research Scholar. Dr. Brenner focuses his clinical and research pursuits on a wide range of motility topics including IBS, constipation, opioid related constipation, fecal incontinence, gastroparesis and scleroderma. He has published more than 125 articles, abstracts, and online materials on these subjects, and has lectured both nationally and internationally in these areas. He acts as a reviewer and editor for multiple GI peer-reviewed journals and is a current associate editor of the American Journal of Gastroenterology. He was a charter board member of the American Gastroenterological Association Academy of GI and Liver Educators, acts as a member of the advisory board for the International Foundation for Gastrointestinal Disorders and serves (research) and has served on multiple ACG committees (education, MOC, digital publications and communications). Dr. Brenner is a fellow of the American College of Gastroenterology and American Gastroenterological Association.

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